BCCs Ultrasound Vs Histology Version 6.0
Research type
Research Study
Full title
Assessing basal cell carcinomas by ultrasound compared with histology
IRAS ID
213318
Contact name
Ernest Allan
Contact email
Sponsor organisation
The Christie NHS Foundation Trust
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
Surgical excision is the most usual (standard) treatment for basal cell carcinomas (BCCs), but in a proportion of cases an alternative treatment that avoids surgery is indicated.
Thickness (and other features) of BCCs can be measured non-invasively by ultrasound both pre- treatment and then post-treatment to assess response to therapy.
However, there is uncertainty about the accuracy of evaluation of thickness of BCCs by ultrasound across sizes and types of BCC and for BCCs on different body sites.
Other studies have been carried out, however, the results are inconsistent (Ballester-Sánchez, 2015; Bobadilla, 2008; Gupta, 1996).
In a prospective study of patients at the Christie NHS Foundation Trust with clinically-diagnosed BCCs (Gorlin’s Syndrome or sporadic), we aim to compare thickness:
- 1) by 35 MHz pulsed ultrasound and
- 2) on histopathology sections (“gold standard”),
- according to diameter (<10 mm;10-20mm; >20mm),
- type (superficial; nodular; morpheic; mixed; nodular cystic);
- site (face; chest; back; upper limbs; lower limbs; trunk).REC name
London - Surrey Borders Research Ethics Committee
REC reference
16/LO/2243
Date of REC Opinion
21 Dec 2016
REC opinion
Further Information Favourable Opinion