Bayraktutan DMT EPC Study
Research type
Research Study
Full title
ENDOTHELIAL PROGENITOR CELLS: POTENTIAL BIOMARKERS FOR DIAGNOSIS AND PROGNOSIS OF ISCHAEMIC STROKE
IRAS ID
206919
Contact name
Ulvi Bayraktutan
Contact email
Sponsor organisation
University of Nottingham
Duration of Study in the UK
3 years, months, days
Research summary
Stroke is a life-threatening condition that occurs due to sudden disruption of blood supply to the brain. Although stroke can happen in all age groups including children, the elderly are at a greater risk of having strokes. Indeed, three-quarter of all strokes are seen in people over the age of 65. Unfortunately, due to short therapeutic window (4.5 h of stroke onset), only 5% of patients can receive the currently available single medical therapy with rt-PA, a clot-busting agent. As recent studies show that bone marrow-derived endothelial progenitor cells may migrate to the site of injury to repair the damaged brain vessels and tissue, it is possible that their numbers and functional capacity may determine the clinical outcome of stroke patients i.e. severely disabled, moderately disabled or no signs at all. This study will assess these parameters in elderly stroke patients compared to their age-matched stroke-free counterparts. In addition to this, the study will also compare the level of these parameters between healthy elderly and healthy young volunteers to discover the specific impact of aging on them. The proposed study will last for three years for which the eligible patients will be recruited from these admitted to Nottingham University Hospitals stroke service. The experiments will be conducted in the Division of Stroke, Clinical Neuroscience at the University of Nottingham.
REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
16/WM/0304
Date of REC Opinion
8 Sep 2016
REC opinion
Further Information Favourable Opinion