Basogranulin as a novel marker of basophil activation
Research type
Research Study
Full title
Basogranulin as a novel marker of basophil activation and mediator of allergic disease
IRAS ID
307259
Contact name
Bashir Ado
Contact email
Sponsor organisation
University of Southampton
Duration of Study in the UK
1 years, 11 months, 15 days
Research summary
Strong evidence suggests the involvement of basophils in allergic diseases and other conditions such as defense against microbial infections. However, their role in these conditions is not clear and their mediators are not well characterized. The host laboratory has identified basogranulin, a protein specifically found in the secretory granules of basophils, as a potential mediator and marker of basophil activation. This study sims to determine the role of basogranulin as a marker of basophil activation. To achieve this we require peripheral blood from healthy volunteers. Basophils will be isolated from the blood within 24 hours of collection will be lysed for further downstream analysis. All materials stored will be acellular and fully anonymised.
REC name
London - Fulham Research Ethics Committee
REC reference
22/PR/0118
Date of REC Opinion
7 Mar 2022
REC opinion
Further Information Favourable Opinion