Basogranulin as a novel marker of basophil activation
Research type
Research Study
Full title
Basogranulin as a novel marker of basophil activation and mediator of allergic disease
IRAS ID
307259
Contact name
Bashir Ado
Contact email
Sponsor organisation
University of Southampton
Duration of Study in the UK
2 years, 1 months, 31 days
Research summary
Strong evidence suggests the involvement of basophils in allergic diseases and other conditions such as defense against microbial infections. However, their role in these conditions is not clear and their mediators are not well characterized. The host laboratory has identified basogranulin, a protein specifically found in the secretory granules of basophils, as a potential mediator. This study intends to determine the role of basogranulin as a marker of basophil activation and as a novel molecule.
To achieve this we need peripheral blood from healthy volunteers. Basophils will be isolated from the blood within 24 hours of collection and the remaining blood discarded. The isolated basophils will be then lysed for further downstream analysis. All materials stored will be acellular and annonymised.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
21/EE/0266
Date of REC Opinion
16 Nov 2021
REC opinion
Unfavourable Opinion