Baseline cortical haemodynamics in MS

• Research type

  Research Study

• Full title

  Investigating baseline cortical haemodynamics in multiple sclerosis

• IRAS ID

  170992

• Contact name

  Nikos Evangelou

• Contact email

  nikos.evangelou@nottingham.ac.uk

• Sponsor organisation

  University of Nottingham

• Duration of Study in the UK

  1 years, 11 months, 27 days

• Research summary

  We aim to characterise the underlying cortical haemodynamics in Multiple Sclerosis (MS). We will assess two techniques for measuring blood flow in the brain: arterial spin labelling (ASL) and dynamic susceptibility contrast (DSC) magnetic resonance imaging in the MS patient group. ASL is a non-invasive technique whilst DSC-MR requires the administration of a tracer intravenously. Previous studies have shown conflicting results from these measurements. Reproducibility of ASL and disease activity will also be assessed through repeated scan sessions. Global perfusion in the MS patient group will be compared to a matched healthy control group.

  We will acquire data from 20 patients with multiple sclerosis and 20 age-matched healthy volunteers.

• REC name

  West Midlands - South Birmingham Research Ethics Committee

• REC reference

  16/WM/0126

• Date of REC Opinion

  21 Apr 2016

• REC opinion

  Further Information Favourable Opinion