Bariatric surgery and Exercise Interventions: Effects on Muscle
Research type
Research Study
Full title
EXPLORING THE SHORT-TERM EFFECT OF BARIATRIC SURGERY ON MUSCLE STRUCTURE AND FUNCTION; FOLLOWED BY A FEASIBILITY ASSESSMENT OF EXERCISE INTERVENTION POST BARIATRIC SURGERY
IRAS ID
311954
Contact name
Iskandar Idris
Contact email
Sponsor organisation
University of Nottingham
Clinicaltrials.gov Identifier
000, 000
Duration of Study in the UK
1 years, 8 months, 2 days
Research summary
The global burden of obesity and its' associated metabolic consequences continue to rise and place additional burden on healthcare systems. Over the last decade, bariatric surgery has emerged as a safe and efficacious intervention for more sustained weight loss as opposed to the more commonplace exercise and dietary measures.
The most common procedures include Roux-en-Y bypass (RYGB) and Sleeve Gastrectomies (SG). Prior to these surgeries, it is mandatory for the patients to undergo a Very Low Calorie Diet (VLCD) to reduce liver size.
Both VLCD and bariatric surgeries lead to significant alteration in both fat and fat-free mass i.e. skeletal muscle mass. Reduction of skeletal muscle mass can cause reduced muscle function and from thereon increased risk of disability, functional decline and frailty. Altogether, risking a worsened quality of life and further institutionalisation.
This study is a feasibility assessment regarding the introduction of a tailored, structured post-bariatric exercise programme for this patient group. The aim is to assess the feasibility of introducing such a programme and also the effects of this intervention on muscle structure and function. Thereby, allowing a greater understanding of mechanisms that underpin changes in muscle structure and function. The study would also allow a platform for future studies to explore strategies to reduce the risk of skeletal muscle loss following VLCD and bariatric surgery and/or set steps in place to preserve muscle function.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
22/WM/0181
Date of REC Opinion
23 Sep 2022
REC opinion
Further Information Favourable Opinion