BAGAGe study
Research type
Research Study
Full title
Using routinely collected kidney biopsy material for subcellular tissue characterisation and quantification of glycosaminoglycans (GAGs)
IRAS ID
352475
Contact name
Nicholas M Selby
Contact email
Sponsor organisation
University Hospitals of Derby and Burton
Duration of Study in the UK
7 years, 10 months, 31 days
Research summary
This is a study in patients with chronic kidney disease (CKD), which describes people who have a sustained (>3months) problems with kidney function or structure. In some patients with CKD, a kidney biopsy is performed to understand the cause of the CKD and provide information about prognosis. The routine analysis of the kidney biopsy measures only some of the processes that can contribute to CKD. At the University of Nottingham, researchers have developed a new electron microsope test that has the potential to measure molecules called glycosaminoglycans (also called GAGs) that currently cannot be detected using standard biopsy analysis. GAGs are important in kidney disease, particularly because the form part of the filtration barrier (in other words, they contribute to one of the main functions of the kidney which is filtering the blood). We would like to perform a study to determine whether this new microscope technique is feasibile to use to analyse kidney biopsies that are performed as part of routine care.
REC name
North East - York Research Ethics Committee
REC reference
25/NE/0044
Date of REC Opinion
13 Feb 2025
REC opinion
Favourable Opinion