Bacterial control of inflammation & neuromarkers in the upper airways
Research type
Research Study
Full title
Bacterial regulation of inflammation and markers of neurodegeneration in the upper airways
IRAS ID
275758
Contact name
Rami Salib
Contact email
Sponsor organisation
Research Integrity and Governance, University of Southampton
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
This ethics outlines an exploratory study to analyse bacteria, inflammatory mediators, proteins and molecules (typically found in fluid surrounding the brain) in nasal sinus tissue.
Tissue and nasal swabs taken intraoperatively will be used to determine if biochemical markers of neurodegeneration (present in fluid surrounding the brain) can be detected in sinus tissue with the goal of creating a less invasive method than is presently available to sample these markers (such as lumbar puncture). Furthermore, we aim to examine the bacteria and inflammatory mediators present in patients with Chronic Rhinosinusitis (also known as sinusitis) to better understand how the bacteria contributes to the disease process and identify targets to better treat the condition.
To perform this task tissue and nasal swabs taken from consenting adults undergoing routine sinus and neurosurgery procedures will be analysed using biochemical techniques to detect the above. This excess tissue would typically be treated as clinical waste. The study will have no bearing on the patient’s treatment or diagnosis and any tissue retrieved will be kept in pseudoanonymised form.REC name
London - Hampstead Research Ethics Committee
REC reference
20/PR/0183
Date of REC Opinion
21 Jul 2020
REC opinion
Further Information Favourable Opinion