BAC study
Research type
Research Study
Full title
To determine physiological and biochemical changes after laparoscopic Cholecystectomy.
IRAS ID
177049
Contact name
Liba Stones
Contact email
Sponsor organisation
Kings College Hospital NHS foundation trust
Duration of Study in the UK
5 years, 0 months, 4 days
Research summary
The gallbladder is a small, pear-shaped pouch in the upper-right part of the abdomen. It stores bile, the digestive fluid produced by the liver that helps to break down fatty foods. Gallstones occur when bile, which is normally fluid, forms stones.In the UK 10-15% of the population has stones in the Gallbladder and on the average more than 50,000 Gallbladder operations are performed each year, making it one of the commonest surgical procedures. The control of bile acid formation is complex and involves several hormones which may have an effect on hunger and food intake. Recently, studies have suggested that bile acids may affect the release hormones which can increase the feeling of fullness after food intake.These may improve blood sugar control which may be a factor in weight loss and improvement of type 2 diabetes after weight loss surgery. In light of this new knowledge, it would be useful to see whether removal of gallbladder causes a change in gut hormone response and bile acid release. This would emphasize the role of bile acids in weight loss management and may help in the development of new weight loss strategies. We hypothesize that bile acids are involved in hunger and weight control through release of hormones and this effect is altered after removal of the gallbladder.The study design is prospective, matched case-control study. Patients will be matched from two groups: a keyhole biliary surgery group(known to have gallstones) and patients from keyhole surgery for other reasons(no gallstones). Both groups will be assessed before and after the surgery for weight, appetite, food preference, hunger and fullness hormones and bile acids changes. Participants will have questionnaires, blood and stool tests, tissue sample, meal challenge and radionucleotide (HIDA) scan. This Study will be performed at King's College Hospital Denmark Hill site.
REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
17/LO/1144
Date of REC Opinion
7 Feb 2018
REC opinion
Further Information Favourable Opinion