Awareness and perceptions of CRC risk and screening in IBD
Research type
Research Study
Full title
A questionnaire study exploring awareness and perceptions around colorectal cancer risk and screening in patients with inflammatory bowel disease
IRAS ID
299854
Contact name
Jimmy K. Limdi
Contact email
Sponsor organisation
Pennine Acute Hospitals NHS Trust, Northern Care Alliance
Duration of Study in the UK
0 years, 7 months, 28 days
Research summary
Inflammatory bowel diseases (IBD), comprising ulcerative colitis and Crohn’s disease, are chronic, relapsing inflammatory conditions affecting the digestive tract. Inflammation in both these conditions can affect all or part of the large bowel; this is termed ‘colitis’. Individuals with long-standing colitis are at increased risk for the development of colorectal cancer (CRC) compared with the general population. IBD is the third greatest risk factor for CRC and accounts for up to 15% of IBD-related mortality. Colitis-related dysplasia (pre-cancerous changes to the bowel lining) seems to be the greatest risk for CRC development. Recent improvements in technology and techniques have led to improved dysplasia detection and CRC detection at a potentially curable stage, thus reducing mortality and morbidity of IBD related CRC. Leading gastrointestinal societies recommend large bowel surveillance colonoscopy for colitis patients to detect dysplasia starting approximately 8-10 years following diagnosis.
There is evidence to show that increased awareness leads to better treatment compliance, quality of life and outcome for people living with IBD. Their engagement remains paramount to improved dysplasia detection. There are limited data currently available on patient perceptions of CRC risk and surveillance practices in IBD in the UK.
The study will be conducted in the Gastroenterology clinics at Pennine Acute Hospitals NHS Trust. A questionnaire regarding knowledge and perceptions around CRC risk in colitis will be completed by consenting patients meeting the study inclusion criteria.We anticipate that this questionnaire study will lead to a better understanding of awareness and perceptions of CRC risk within a mixed outpatient UK IBD population, with a view towards identifying areas of development in CRC surveillance and thus improving overall quality of care for people living with IBD.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
21/PR/0690
Date of REC Opinion
14 Jun 2021
REC opinion
Further Information Favourable Opinion