Autonomic modulation on visceral pain hypersensitivity in NERD

• Research type

  Research Study

• Full title

  A randomized single blinded parallel study to investigate the effect of physiological and psychological modulation of the autonomic nervous system on oesophageal pain hypersensitivity in patients with non-erosive reflux disease (NERD).

• IRAS ID

  167813

• Contact name

  Qasim Aziz

• Contact email

  q.aziz@qmul.ac.uk

• Sponsor organisation

  Queen Mary University of London

• Duration of Study in the UK

  2 years, 0 months, 1 days

• Research summary

  This is a randomized single blinded parallel study to investigate the effect of physiological modulation of the autonomic nervous system on oesophageal pain hypersensitivity in patients with non-erosive reflux disease (NERD). We aim to evaluate the effect of slow deep breathing and sham breathing on oesophageal pain hypersensitivity in patients with NERD. The primary endpoint is the difference in lag time to perception of first sensation between slow deep breathing and sham breathing following oesophageal acid perfusion. We aim to recruit 80 participants.

• REC name

  London - Harrow Research Ethics Committee

• REC reference

  15/LO/1454

• Date of REC Opinion

  13 Jan 2016

• REC opinion

  Further Information Favourable Opinion