Autologous Platelet Adjuncts In Large or Failed Macular Holes
Research type
Research Study
Full title
Effect of Adjunctive Autologous Platelet Concentrate In Surgery For Large or Failed Macular Holes
IRAS ID
178462
Contact name
D Alistair H Laidlaw
Contact email
Sponsor organisation
Guy's & St Thomas' Foundation NHS Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
A macular hole is a split in the central retina. It seriously and permanently impairs vision. Success rates for surgery in small and medium sized macular holes exceed 95% in terms of both closing the hole and improving vision. Holes are sized using an OCT scanner, which is a standard clinical test at the mid retinal level. Holes larger than 700 microns have a lower rate of success <75% overall, as do redo procedures in previoulsy failed surgery. Intraocular autologous platelet injection at the end of the procedure used to be employed as a routine adjunct to macular hole surgery. This has fallen out of use in most centres because alternative techniques evolved which rendered them superfluous in most cases.
There are persisting anecdotal reports of successful use of autologous platelet concentrate in high risk holes but this has not been systematically investigated. This study therefore aims to investigate the efficay of use of adjunctive autologous platelet concentrtate in patients undergoing surgery for large or redo macular holes.REC name
London - London Bridge Research Ethics Committee
REC reference
15/LO/2075
Date of REC Opinion
8 Feb 2016
REC opinion
Further Information Favourable Opinion