Audiovestibular function in infratentorial superficial siderosis AViSS
Research type
Research Study
Full title
CLINICAL AND IMAGING BIOMARKERS OF AUDIOVESTIBULAR FUNCTION IN INFRATENTORIAL SUPERFICIAL SIDEROSIS
IRAS ID
255835
Contact name
Doris Eva Bamiou
Contact email
Sponsor organisation
Univeristy College London
Clinicaltrials.gov Identifier
Z6364106/2019/05/14, Sponsor (UCL) Data Protection Registration number
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
One in six people In the UK and over 400 million people worldwide have disabling hearing loss. This figure will double by 2050 as predicted by WHO. There is an urgent need to improve our knowledge regarding hearing loss, its underlying mechanisms, optimal diagnostic modalities, reliable and accurate functional and imaging bio-markers.
A less-well studied condition associated with progressive hearing loss is infratentorial superficial siderosis (iSS). It results from iron deposition along the surfaces of brain structures which control hearing and balance. It is currently considered uncommon, but may well be under-recognised and therefore under-reported. Despite its severity, our current understanding of its impact on the hearing (auditory) and balance(vestibular) functions is limited, and this has an adverse impact on the treatment offered to these patients. Due to its significant morbidity and progressive nature, there is a clear need to improve our understanding of the audiovestibular dysfunction resulting from iSS.
We aim to comprehensively assess audiovestibular function in iSS compared to age-related hearing loss and the controls/normative data and as a means to quantify deficits for monitoring disease progression and response to treatment, to assess the impact on the quality of life, to correlate the radiological and functional findings in iSS and as a means of imaging marker of auditory and vestibular dysfunction.
Study Methods
Three groups of participants will be recruited into the study: a)participants with a diagnosis of iSS (siderosis group); b)participants with age-related hearing loss (ARHL group); c)participants with no previous history of hearing loss (control group). The groups will undergo audiological(all study participants) and vestibular tests (siderosis group participants only) and the findings will be analysed and compared between the groups and with normative data. The recruitment phase will last 24 months. The overall study duration will be three years, including data analysis and write-up.REC name
London - Surrey Research Ethics Committee
REC reference
19/LO/1162
Date of REC Opinion
9 Aug 2019
REC opinion
Further Information Favourable Opinion