ATRX IHC in IDH-1 mutated low grade gliomas

• Research type

  Research Study

• Full title

  Anti-ATRX Immunohistochemistry in IDH-1 Mutated Low Grade Gliomas: Can this Antibody Refine the Classification of Morphologically Ambiguous Low Grade Gliomas in a Clinical Setting.

• IRAS ID

  202304

• Contact name

  Pohl Ute

• Contact email

  ute.pohl@bhrhospitals.nhs.uk

• Sponsor organisation

  Barking Havering and Redbridge University NHS Trust

• Duration of Study in the UK

  0 years, 3 months, 0 days

• Research summary

  This project aims to aid the further classification of a subtype of brain tumours using in-house testing methods. First, to see if the in-house testing results (immunohistochemistry) correlate with the molecular testing that is sent to a regional centre.

  Secondly; as this type of brain tumour typically shows a mutation, which is identified by a loss of staining, the use of a double staining technique will identify any tumour cells and then aid in the assessment of their anti-ATRX status. This will better enable interpretation by the Consultant Histopathologist.

• REC name

  South Central - Hampshire A Research Ethics Committee

• REC reference

  16/SC/0367

• Date of REC Opinion

  5 Jul 2016

• REC opinion

  Favourable Opinion