AtriumGen Study
Research type
Research Study
Full title
Study of biomarkers derived from left atrium electroanatomic mapping of patients undergoing first time atrial fibrillation ablation.
IRAS ID
344977
Contact name
Rui Providência
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
EP/Z000211/1, UKRI EPSRC Funder ; Z6364106/2025/01/106 health research, UCL Data Protection Registration Number
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
The arrhythmia atrial fibrillation (AF) is the most common heart rhythm disease, yet its underlying disease pathology
remains to be clearly elucidated. Given its association with aging populations and the burden it imposes on
healthcare systems due to increased hospital attendances for symptoms of arrhythmia and heart failure exacerbation,
it is likely to have an increasing economic impact on developed economies around the world. Furthermore, whilst AF
is not directly linked to high mortaility, it does come with a significant symptom burden and tackling the arrhythmia has
been shown to improve quality of life when successful.
Recent innovations in AF management have mainly come from new approaches to AF ablation, a procedure that
isolates the electrical triggers for AF in the heart. In the last decade however, development of new pharmacological
therapies has stalled. These ablation procedures provide data on the structural and electrical properties of the atrium,
where this arrhythmia occurs. It is possible therefore that data from these procedures can be explored to find new
pharmacological therapies for atrial fibrillation as well as developing a better understanding of the underlying disease
process.
Our project would be eligible to any patient undergoing a routine AF ablation within which electrical mapping of their
atrium occurs. Additional samples would be taken for genetic sequencing, in order to find associations between
genes and the electrical and structural properties of the atrium gleaned from the data obtained during the procedure.REC name
London - Bloomsbury Research Ethics Committee
REC reference
25/LO/0424
Date of REC Opinion
28 Jul 2025
REC opinion
Further Information Favourable Opinion