Asthma:Phenotyping Exacerbations 2
Research type
Research Study
Full title
Phenotyping Asthma Exacerbations: A Longitudinal Cohort Study 2
IRAS ID
266535
Contact name
Tim Harrison
Contact email
Sponsor organisation
The University of Nottingham
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Asthma exacerbations (asthma attacks) are very common in the UK. They are frightening for patients, expensive for the health service and occasionally lead to avoidable deaths.
Despite the importance of asthma attacks, they remain poorly defined. Although some of the triggers for asthma attacks are understood, the resultant phenotypes, or characteristics, of attacks are not. It is also unclear whether there are differences in the profiles between patients who have frequent exacerbations and those whose exacerbations are infrequent. Increased knowledge about the nature of asthma attacks, may lead to the development of more targeted treatment options.
This study aims to phenotype asthma attacks in a cohort of patients thought to be at a low risk of an exacerbation and relate them to the stable asthma phenotype. We will also compare the features of this cohort to the APEX cohort of participants who are in a perceived higher risk group.
We will achieve this by establishing a group of well characterised participants with asthma, who have had an asthma exacerbation during the last 5 years. They will be phenotyped at a Baseline Visit and then followed over a period of time. They will be asked to attend for an annual review and for an unscheduled visit when they perceive their asthma symptoms are worsening. During this visit, they will be assessed by a doctor and potentially undergo the exacerbation visit.
The study is planned to last for 3 years, with a recruitment period of 2 years and will include 100 participants with asthma.
REC name
HSC REC A
REC reference
19/NI/0149
Date of REC Opinion
20 Sep 2019
REC opinion
Further Information Favourable Opinion