Asthma Remission Study
Research type
Research Study
Full title
A retrospective chart review to investigate clinical remission in patients with severe asthma treated with biologics in the United Kingdom National Health Service
IRAS ID
335318
Contact name
Michael Watt
Contact email
Sponsor organisation
AstraZeneca
Duration of Study in the UK
0 years, 2 months, 29 days
Research summary
Asthma is a common lung condition that causes occasional breathing difficulties and affects around 5.4 million people in the UK of all ages. Common symptoms can include wheezing when breathing, breathlessness, a tight chest and coughing. However, these symptoms can get worse and lead to an asthma attack which can be fatal.
There is currently no cure for asthma but there are treatments that can help keep the symptoms under control. The main types of treatment include reliever inhalers used when needed quickly to reverse asthma symptoms for a short time, and preventer inhalers that are used everyday to prevent symptoms for starting. Unfortunately, not all patients are able to control their asthma on these treatments alone.
Biologic treatments, also known as monoclonal antibodies, have been introduced to treat certain types of severe asthma over recent years. These specialist treatments use antibodies produced from cells in a laboratory to help reduce inflammation and might offer the possibility of higher levels of disease control including the reduction or absence of symptoms and normal lung function. This higher level of disease control is called remission.
This study aims to understand whether or not remission is possible in patients with severe asthmas treated with biologics in the NHS.
This study will take place a 4 specialist asthma centres in the UK and seeks to include retrospective data from approximately 450 adult patients that were treated with biologics as part of routine care between 01 October 2021 and 30 September 2022.
Data will be collected directly from medical records and entered into the study database in a pseudonymised format by members of the direct care team ready for analysis. There will be no involvement from patients as part of the study.
REC name
South West - Frenchay Research Ethics Committee
REC reference
23/SW/0146
Date of REC Opinion
4 Dec 2023
REC opinion
Favourable Opinion