Association of fitness and physical stress with metabolic surgery
Research type
Research Study
Full title
Assessment of functional capacity and its association to perioperative stress evaluated via glycaemic and cardio-vascular variability – a pilot study
IRAS ID
232965
Contact name
Jeffrey Stephens
Contact email
Sponsor organisation
Abertawe Bro Morgannwg University Health Board
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Metabolic (bariatric) surgery is an effective tool to treat obesity and type 2 diabetes. In preparation for surgery, regular physical exercise is advocated to increase functional capacity and this has been shown to relate to improved recovery from surgery. Any surgery results in physiological stress which has been poorly quantified in patients with obesity and type 2 diabetes undergoing metabolic surgery.
We wish to explore the relationship between physical fitness and surgery-induced physiological stress in patients undergoing metabolic surgery.
This knowledge has the potential to improve the perioperative care and early outcome following surgery.The aim of this pilot-study is to investigate physiological stress markers which may be altered during and in the early period after surgery in relation to physiological fitness. Changes in heart-rate variability (HRV) and in interstitial glucose variability (IGV) have previously been related to stress-related changes within the autonomic nervous system. These markers will be measured using flash-glucose monitoring and electrocardiogram (ECG). Physiological fitness will be measured by cardio-pulmonary exercise testing, the timed-up and go test, a 6-minute walk test and the star-excursion balance test. In addition, the effects of surgical-induced stress on mental performance, biochemical and cardiovascular markers will be measured.
REC name
Wales REC 7
REC reference
17/WA/0292
Date of REC Opinion
28 Sep 2017
REC opinion
Favourable Opinion