Association between RhD pos neonate weight and FMH in Rh neg women
Research type
Research Study
Full title
The examination if there is any association between RhD positive neonate weight and large Feto-maternal haemorrhage in RhD negative women
IRAS ID
241027
Contact name
Robert Reilly
Contact email
Sponsor organisation
University of Greenwich
Duration of Study in the UK
0 years, 2 months, 28 days
Research summary
If neonatal weight determines the severity of Fetal-Maternal Hemorrhage in Rhesus D negative women, then neonatal weight becomes one of risk factors that have to be maintained during the gestational time to avoid possible sensitization.
During the gestation time in every woman, fetal blood can cross the placenta and enter maternal circulation, causing Feto-Maternal Hemorrhage (FMH). The problem occurs if a pregnant woman is Rhesus D negative and carries Rhesus D positive fetal. In order to avoid the sensitization the pregnant RhD negative pregnant women is issued with prophylactic anti-D. The sensitization depends on many factors including the volume of FMH, mother’s immune system and if prophylactic anti-D was given or not. The recent study has been done, where they discovered that obese women have a higher chance to have larger neonate at delivery which may lead to extended bleed. It was found that from 32 weeks, the fetuses weight started to increase in obese women more than non-obese. Is it having large neonate would always lead to extended bleed in mother or the bleeding is a result of RhD incompatibility? Is it having small neonate could lead to lower or no FMH at all? The finding would add some knowledge to current findings we know and would improve patient’s care management.
The study will be done on Beckman Coulter Flow Cytometry analyser at Haematology laboratory at Maidstone and Tunbridge Wells NHS Trust. Samples will be annonymised by work collegue. The neonate weight data would be given anonymously as well. Anonymous samples would be ones which would be initially sent for testing in the laboratory and completed before being anonymised and used for research. No any extra samples would be needed.
It will be a pilot study.REC name
Wales REC 7
REC reference
18/WA/0174
Date of REC Opinion
9 May 2018
REC opinion
Unfavourable Opinion