Assessment of tissue oxygen consumption with NIRS VOT and O2K - V 1.2

• Research type

  Research Study

• Full title

  Assessment of tissue oxygen consumption with a bedside non-invasive measure and an in-vitro technique in critically ill children

• IRAS ID

  148546

• Contact name

  Mark Peters

• Sponsor organisation

  University College London - Institute of Child Health

• Duration of Study in the UK

  2 years, 0 months, 0 days

• Research summary

  Oxygen is a pre-requisite for energy production in the human body. In health, the oxygen delivered to the tissues is closely balanced with the amount of oxygen used by the tissues. Critical illness has a harmful effect on both the oxygen delivery and utilisation.
  We hypothesise that the human body adapts to the low levels of oxygen by using less during recovery from critical illness. We test this hypothesis by serially measuring oxygen utilisation by the muscles in the forearm. We will use near infra-red spectroscopy (NIRS) for this purpose. If we were to prove the hypothesis that human body adapts to low oxygen levels, future management of critically ill patients might be significantly modified.
  Mitochondria are structures within cells where oxygen is used to produce energy. Their number varies between tissues. As a second part of our project we explore the impact of this variation in number on oxygen use. For this we will assess the relationship between the measured oxygen use by NIRS (from muscle)and Oxygraph-2k analyser (blood).
  

  
  

• REC name

  London - Hampstead Research Ethics Committee

• REC reference

  14/LO/1819

• Date of REC Opinion

  10 Oct 2014

• REC opinion

  Favourable Opinion