Assessment of the MEST criteria in childhood HSP nephritis
Research type
Research Study
Full title
ASSESSMENT OF THE OXFORD CLASSIFICATION (MEST CRITERIA) IN IDENTIFYING PATIENTS WITH POOR OUTCOMES FOLLOWING HENOUCH-SCHONLEIN PURPURA IN CHILDHOOD
IRAS ID
202763
Contact name
Andrew Lunn
Contact email
Sponsor organisation
Nottingham University Hospitals NHS Trust
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
Henoch-Schonlein Purpura (HSP) is a condition in which the immune system reacts against the body’s own small blood vessels. It can occur at any age but commonly affects children. It typically affects small blood vessels in the skin (causing a typical purple rash), the joints, the bowel and the kidney. In most children it improves without specific treatment but in some children there are long term consequences mainly related to how active the inflammation is within the kidneys.
In children who are severely affected a renal biopsy is done. This is when a small amount of tissue is taken from the kidney and studied under a microscope. Children who have more severe grades of inflammation are then treated with medicine to reduce the inflammation.
Traditionally, the International Study of Kidney Disease in Children (ISKDC) classification is used to grade the amount of inflammation seen when the kidney is studied under the microscope. Research studies have not consistently been able to show that children with the more severe grades of inflammation when using the ISKDC have more severe long term outcomes and therefore need more treatment.
An alternative method for grading inflammation and damage in renal biopsies is the Oxford Classification or MEST criteria. Our study will assess the effectiveness of the MEST criteria in predicting long term outcomes of patients with HSP nephritis in Nottingham. This study will then compare the usefulness of the MEST criteria and the ISKDC classification in predicting long term outcomes of patients with HSP nephritis.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
16/EM/0419
Date of REC Opinion
4 Oct 2016
REC opinion
Further Information Favourable Opinion