Assessment of peptides to reduce inflammation in acutely burned skin
Research type
Research Study
Full title
An ex-vivo assessment of pro-inflammatory cytokine release from acutely burned skin and ex-vivo assessment of the efficacy of JEL2603 and other peptides at reducing the cytokine release compared to positive and negative controls.
IRAS ID
304771
Contact name
Fadi Issa
Contact email
Sponsor organisation
Carocell Bio Limited
Duration of Study in the UK
0 years, 2 months, 29 days
Research summary
Severe burn injuries are not only life threatening but can be significantly disfiguring leading to a low quality of life and mental health issues for the survivors. The ultimate aim of this study is to produce a topical peptide that reduces inflammation and scarring in burns victims.
Having had promising results in the laboratory using new peptides to reduce inflammation, this study hopes to reproduced the results and evaluate the peptides ability to reduce inflammation in acutely burned human skin.
In order for scientific evaluation of the peptides on acutely burned human skin, this study aims to recruit 2 groups of participants:1. participants who have unfortunately sustained significant burn injuries requiring burns excisional surgery - the excised burned skin, which is discarded in standard practice, will be collected and analysed with the new peptides in the laboratory
2. participants undergoing elective breast reconstruction surgery with DIEP free flap - a small area at the edge of the flap (usually excised and discarded in standard practice) will be burned under controlled conditions, excised and examined with the new peptides in the laboratory.
The study will be conducted at Stoke Mandeville Hospital, Aylesbury, and the tissue samples will be further analysed in a laboratory in Cheshire.
This is potentially a ground breaking advance in burns surgery and management as reducing inflammation can reduce fluid loss, accelerate healing and reduce scarring, which can significantly improve the quality of life in patients with severe burns injuries.
REC name
London - London Bridge Research Ethics Committee
REC reference
22/PR/0082
Date of REC Opinion
23 Feb 2022
REC opinion
Further Information Favourable Opinion