Assessment of Pancreas Allografts Using Novel Magnetic Resonance
Research type
Research Study
Full title
Assessment of Pancreas Allografts Using Novel Magnetic Resonance Techniques
IRAS ID
235856
Contact name
David van Dellen
Contact email
Sponsor organisation
Central Manchester University Hospitals NHS Foundation Trust
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
At present methods of detecting pancreas transplant rejection require biopsy of the transplanted organ. This requires the passage of a needle through the abdominal wall into the implanted organ. This process is associated with complications in a significant proportion of cases, and the sample acquired is often inadequate. The sample that is acquired is then assessed for signs of rejection that can be seen in the cells that make up the pancreas. In particular this looks for fibrosis, inflammation and fat content.
These changes can be detected in other organs using Magnetic Resonance Imaging (MRI) but this technology has not previously been tested in pancreas transplants. This study will apply MRI techniques to the context of pancreas transplant to allow assessment of rejection and functional capacity without the need for biopsy.
This study will test this technology in pancreas transplants. The aim is that rejection can be discovered earlier and without the complications associated with biopsy, which would improve outcomes significantly for patients.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
19/NW/0440
Date of REC Opinion
16 Aug 2019
REC opinion
Further Information Favourable Opinion