Assessment of COPD and COPD/OSA Overlap
Research type
Research Study
Full title
Comprehensive Assessment of COPD Patients and COPD/OSA Overlap Syndrome Patients to understand cardiovascular risk and changes in cognitive function
IRAS ID
353621
Contact name
Swapna Mandal
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106/2025/01/68, The UCL data registration number
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
This study explores the impact of chronic obstructive pulmonary disease (COPD) and the overlap of COPD with obstructive sleep apnea (OSA) on cardiovascular health, cognitive function, and quality of life. COPD is a chronic lung disease causing breathing difficulties, and OSA is a sleep disorder where breathing is interrupted during sleep. When both conditions occur together (COPD/OSA overlap syndrome), the health risks, including heart problems and cognitive decline, are significantly increased compared to having either condition alone.
The study will include 49 adult participants divided into three groups: those with COPD only, those with treated COPD/OSA overlap syndrome (using CPAP therapy), and those with untreated COPD/OSA overlap syndrome. Participants will be assessed at three time points: baseline, 3 months, and 12 months. Assessments will include tests for cognitive function (Montreal Cognitive Assessment), cardiovascular health (using methods like pulse wave velocity, EndoPAT, Retinal imaging), and quality of life (via validated questionnaires).
By comparing these groups, the study aims to identify differences in cognitive function, cardiovascular risk, and quality of life. Additionally, the study will evaluate the effectiveness of CPAP therapy in improving outcomes for patients with COPD/OSA overlap syndrome.
The findings will help improve our understanding of the combined effects of COPD and OSA and guide better treatments to improve patients' health and well-being.
REC name
London - Queen Square Research Ethics Committee
REC reference
25/PR/0866
Date of REC Opinion
9 Jul 2025
REC opinion
Favourable Opinion