Assessment and characterization of microvascular function by DOT

• Research type

  Research Study

• Full title

  Quantitative assessment and characterization of microvascular function using diffuse optical tomography

• IRAS ID

  142540

• Contact name

  TIMOTHY JA CHICO

• Contact email

  T.J.CHICO@SHEFFIELD.AC.UK

• ISRCTN Number

  ISRCTN27674506

• Duration of Study in the UK

  1 years, 11 months, 31 days

• Research summary

  Research Summary:
  Atherosclerosis (narrowing of arteries) is the commonest UK cause of death. Atherosclerosis affects the ability of small blood vessels to expand (called microvascular function). If we could measure microvascular function accurately and reliably, we might be able to identify people with early atherosclerosis. This could allow us to identify people at risk of heart attack, or test treatments to prevent atherosclerosis.

  We think a technique called diffuse optical tomography (DOT) that painlessly shines light into the arm and measures the reflections before, during, and after a blood pressure cuff is inflated for 5 min may allow us to assess microvascular function more accurately than existing tests.

  In this study we will recruit 30 patients with diabetes, and 30 patients who have previously had a heart attack (myocardial infarction). We expect that these people will have abnormal vascular function. We will measure their vascular function by DOT and compare this with patients of similar ages but without diabetes or a previous heart attack.

  We will also measure vascular function in 50 patients who are awaiting a test called an angiogram to determine whether they have heart disease. We will then compare the results of our test with the results of the angiogram.

  Our work will tell us whether DOT can detect differences in microvascular function between healthy people and those with atherosclerosis or diabetes, or can predict which patients have coronary artery disease on an angiogram.

  Lay Summary of Results:
  Not available

• REC name

  Yorkshire & The Humber - South Yorkshire Research Ethics Committee

• REC reference

  15/YH/0272

• Date of REC Opinion

  21 Sep 2015

• REC opinion

  Further Information Favourable Opinion