Assessing the biology of the injured lung - Version 1
Research type
Research Study
Full title
Assessing the processess of inflammation and repair using a human lung disease model
IRAS ID
129933
Contact name
James E Fildes
Contact email
Sponsor organisation
University Hospital of South Manchester
Research summary
Respiratory diseases represent a significant burden on the NHS, with over 6 million people in the UK suffering from either COPD or asthma alone. This has led to respiratory disorders becoming the third leading cause of death in England. As such, there is significant interest in understanding disease processes that occur, with the aim of reducing the incidence of these inflammatory disorders.
This study aims to understand the inflammatory profile within diseased/injured tissues using a human diseased lung model, with the ultimate aim of identifying novel therapeutic targets. As there is a government initiative to reduce the use of animals in research, the development of human models is essential.
Diseased lungs will be obtained via explantation prior to lung transplantation. Lungs will either be placed onto an artificial ventilation and perfusion circuit, known as ex-vivo lung perfusion (EVLP), or dissected to generate a morphologically accurate model of the lung. EVLP allows lungs to be kept outside the human body for a maximum of 12 hours, allowing the direct assessment of the organ. Using this procedure, we aim to define the inflammatory cascade and mechanisms by which the lung adapts to damage(remodelling) or repair. In the tissue section model, we will assess how immune cells respond, interact and migrate into the injured lung. The effect of gas delivery on lung cells will also be assessed using this model.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
14/NW/0260
Date of REC Opinion
26 Jun 2014
REC opinion
Further Information Favourable Opinion