Assessing oedema in neonates and infants with NIR hyperspectroscopy_v1
Research type
Research Study
Full title
Assessment of the formation of generalised oedema and fluid balance in critically ill neonates and infants using Near Infrared Hyperspectroscopy (NIRH); a feasibility study
IRAS ID
306053
Contact name
Meha Qassem
Contact email
Sponsor organisation
City, University of London
Duration of Study in the UK
0 years, 5 months, 30 days
Research summary
In critically ill neonates and infants, fluid balance is imperative in maintaining haemodynamic stability. Excess fluid administration can lead to generalised oedema, a common condition which results from fluid overload and is associated with many unfavourable effects and increases the risk of morbidity and mortality. At present, fluid administration can be classically assessed using a weight-based formula which depends on gestational age, post-birth age and the patient’s clinical status. Other methods include simple observation, measuring fluid input and urine output and overall weight gain. Unfortunately, these procedure are limited in many ways and fail to prevent cases of fluid overload. They are also time-consuming and do not permit continuous monitoring of fluid status. This project aims to investigate a new method for real-time and contact-free monitoring of fluid balance using Near Infrared Hyperspectroscopy and multivariate modeling. The research aims to utilise this technique to develop hyperspectral fluid distribution maps in critically ill neonates and infants as well as build quantitative models for accurate determination of fluid balance. The project will address the various aspects of the research through a clinical and engineering collaborative partnership that will combine experimental and computation approaches.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
22/EE/0256
Date of REC Opinion
14 Feb 2023
REC opinion
Further Information Favourable Opinion