Assessing Bronchial Hyper-reactivity in a Birth Cohort Study
Research type
Research Study
Full title
Assessment of Bronchial Hyper-reactivity in the lsle of Wight Birth Cohort at 26-years to Support Characterisation of Asthma Remission and Persistence from Childhood to Adulthood.
IRAS ID
196787
Contact name
Ramesh J Kurukulaaratchy
Contact email
Sponsor organisation
Isle of Wight NHS Trust
Duration of Study in the UK
1 years, 6 months, 26 days
Research summary
Long-term research following populations over time has identified different types of asthma. These may appear at different ages, varying in nature and severity, with some forms of asthma proving long-lasting while others are outgrown. A key area for future research is why some people outgrow their asthma and whether that provides clues on how to combat this common disease. To answer that question ideally requires a well characterised study population that is followed over many years plus accurate information that reliably proves loss of asthma. One tool to support that process is measurement of a key feature of asthma called bronchial hyper-responsiveness which reflects the twitchiness of the airways in asthmatics.
The lsle of Wight Cohort (containing 1456 subjects) was established in 1989 to study the natural history of asthma, has been followed regularly in the first 18 years, and is now being re-assessed at 26 years. This proposal is for a sub-study at 26 years to assess bronchial hyper-responsiveness via bronchial challenge tests in a subset of these subjects (150) who have previously attended throughout the study. These will be undertaken in subjects at 26 years who in the first 18 years had early persistent asthma, loss of asthma,or never had asthma. These findings will help assess the later outcomes of asthma patterns in the first 18 years with the aim of better understanding what is associated with loss or persistence of asthma. Understanding how people outgrow asthma could help direct future treatment development with potential to hugely benefit the 5 million asthma sufferers in the UK.
REC name
HSC REC B
REC reference
16/NI/0170
Date of REC Opinion
15 Aug 2016
REC opinion
Further Information Favourable Opinion