Assess metabolic profiling strategies for CVD nutritional management
Research type
Research Study
Full title
Assessing metabolic profiling strategies for nutritional management of cardiovascular disease risk
IRAS ID
237962
Contact name
Isabel Garcia Perez
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
2 years, 3 months, 28 days
Research summary
Cardiovascular diseases (CVD) account for approximately a third of the total deaths worldwide. Although genetic predisposition plays a role in CVD, diet, is known to modify disease risk. However, it is known that people respond differently to dietary changes and in order to find the best strategy for an individual it is necessary to identify objective measures of dietary adherence and dietary effect. The premise of this proposal is that metabolic profiling can be used to improve the accuracy of monitoring dietary intake, behaviour and adherence to diet guidelines for people at risk of CVD and can be a useful tool for establishing inter-individual variation in response to diet. Thus this project aims to evaluate the applicability of providing a metabolically-informed personalised dietary advice to help CVD-risk people to change their dietary habits within their own environment.
First, a group of people at risk of CVD will be housed in clinical unit (CRF-Hammersmith) for 4 nights and 5 day on 2 occasions. Their response to a healthy and an unhealthy diet over a 5-day period will be monitored through multiplatform analysis of urine and blood which will map the levels of many different molecules. These profiles will be used to build a model for predicting whether patients are following a healthy diet, with specific molecules representing intake of individual foods.
Secondly, the model will be tested on individuals at risk of CVD, in their home environment and the viability of using these metabolic profiles as an adjunct to nutritional management in a clinical setting will be evaluated. The intervention group will receive advice for 12-weeks based on measurements of their urinary metabolic profiles and the effect of metabolically-informed personalised dietary advice on reducing CVD risk factors will be compared with a control group receiving standard dietary advice by the dietician.REC name
London - Dulwich Research Ethics Committee
REC reference
18/LO/2042
Date of REC Opinion
1 Mar 2019
REC opinion
Further Information Favourable Opinion