ASPIRE Registry
Research type
Research Database
IRAS ID
305428
Contact name
David Kiely
Contact email
Research summary
The ASPIRE Registry (Assessing the Severity of Pulmonary Hypertension In a Pulmonary Hypertension REferral Centre): improving our understanding of pulmonary hypertension
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
22/EE/0011
Date of REC Opinion
24 Feb 2022
REC opinion
Further Information Favourable Opinion
Data collection arrangements
Population to be studied: all patients evaluated for suspected pulmonary vascular disease attending Sheffield Teaching Hospitals NHS Foundation Trust.
Data to be stored:
- demographics, including age, sex, height, weight.
- standard clinical physiological measurements including, breathing test and spirometry results, exercise test data, airway reactivity measures
- laboratory test results e.g. blood tests, clinical chemistry etc.
- imaging and radiological data e.g. x-rays, Magnetic Resonance Imaging, CT scans etc.
- other assessments including right heart catheterisation data
- medications and treatments data.Only data previously collected during the course of normal clinical care will be analysed.
Research programme
Pulmonary Hypertension (PH) is a rare and serious disorder. It is challenging to diagnose and treat. The Sheffield Pulmonary Vascular Diseases Unit based at the Royal Hallamshire Hospital is one of seven nationally designated adult Pulmonary Hypertension centres in the UK delivering highly specialised care for patients with PH. It is one of the largest European centres and is involved in multiple pivotal international collaborative studies. The SPVDU works closely with partners in the University of Sheffield Department of Infection, Immunity and Cardiovascular Disease who undertake leading research in new lung imaging techniques, understanding mechanisms of disease, and development of novel targets for therapy. Our aim is to review the use of investigations frequently used in the assessment of suspected PH in a broad group of patients, to assess their utility in diagnosing and assessing the severity of PH. We also aim to explore new applications of these routine investigations to determine whether we can improve the assessment of patients and also provide pilot data for hypotheses for new investigative approaches for patients with suspected pulmonary vascular disease. In a similar way we aim to identify any differences in treatment outcomes in the various groups of patients with PH.
Research database title
The ASPIRE Registry (Assessing the Severity of Pulmonary Hypertension In a Pulmonary Hypertension REferral Centre): improving our understanding of pulmonary hypertension
Establishment organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Establishment organisation address
8 Beech Hill Road
Sheffield
S5 7AU