Asbestos in pleural tissues v1.0

• Research type

  Research Study

• Full title

  Revealing the presence and distribution of asbestos in human pleural tissues from exposed subjects

• IRAS ID

  353433

• Contact name

  Fabrizio Bardelli

• Contact email

  fabrizio.bardelli@cnr.it

• Sponsor organisation

  CNR-Nanotec

• Duration of Study in the UK

  0 years, 0 months, 4 days

• Research summary

  Asbestos-induced malignant mesothelioma develops in the lung lining (pleura) and not in the lung itself (parenchyma). However, pleural tissue is rarely studied. We want to study pleural tissue using x-ray phase-contrast microtomography (XPCT) to reveal the possible presence and distribution of asbestos bodies (AB, asbestos plus the ferruginous coating it develops in biological tissues) in autoptic pleural tissue samples from subjects with prolonged occupational exposure to asbestos. The results will help clarify the lung-pleura transport mechanism and may support the hypothesis that the AB may have a possible role in the pathogenesis of asbestos-related diseases.

• REC name

  London - Camden & Kings Cross Research Ethics Committee

• REC reference

  24/PR/1655

• Date of REC Opinion

  23 Jan 2025

• REC opinion

  Favourable Opinion