AS 500 study
Research type
Research Study
Full title
CMR predictors of mortality in patients undergoing Surgical AVR or TAVI for severe Aortic Stenosis (AS)
IRAS ID
141186
Contact name
John P Greenwood
Contact email
Sponsor organisation
University of Leeds
Research summary
We aim to complete a multicentre observational study (comprising groups from Leeds, Leicester, London, Oxford and Edinburgh) with the intention of amassing a cohort of ~500 patients, all of whom have had cardiac MR prior to receiving a Surgical Aortic Valve Replacement (SAVR) or Transcatheter Aortic Valve Implantation (TAVI) for severe Aortic Stenosis (AS). The intended period of follow-up is 2 years.
Studies using Cardiac Magnetic Resonance Imaging (CMR) to predict mortality in severe AS and in response to AVR are few; and in the response to TAVI completely lacking. Due to the lack of long-term results, TAVI remains restricted to high-risk and inoperable patients based upon their STS (Society of Thoracic Surgeons) risk score or EuroSCORE. Neither of these systems are validated for the prediction of long-term prognosis or mortality post TAVI and at present there is no dedicated scoring system currently available.
There are an estimated 5000 aortic valve replacements and 500 TAVI procedures per year in the UK. We hope to categorically identify specific MRI-derived measures that hold prognostic significance in patients with severe AS undergoing intervention. Furthermore, we hope to test the hypothesis that cardiac MRI brings incremental value to commonly used scoring systems, and that as such cardiac MRI could be considered more routinely in the clinical management of severe AS.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
13/NW/0832
Date of REC Opinion
22 Nov 2013
REC opinion
Favourable Opinion