Arterial Resection for Locally Advanced Pancreatic Cancer

• Research type

  Research Study

• Full title

  ARTERIAL RESECTION IN SURGERY FOR LOCALLY ADVANCED PANCREATIC CANCER

• IRAS ID

  145270

• Contact name

  Giuseppe Fusai

• Contact email

  g.fusai@ucl.ac.uk

• Sponsor organisation

  University College London

• Research summary

  Worldwide, pancreatic cancer is the 13th most common cancer but the 8th most common cause of death with little improvement in survival over the last few decades. Surgical resection remains the only potentially curative treatment but it is feasible in approximately 15-20% of patients, as the majority present with metastases or locally advanced disease.
  Locally advanced pancreatic cancer with vascular involvement remains a surgical challenge because of the higher perioperative risk and the uncertainty of a survival benefit. Whilst portal vein resection has today an established role as several studies have demonstrated a long term survival and perioperative morbidity comparable to standard pancreatectomy, there isn’t yet a consensus on arterial resection (AR).Recent advances in clinical practice with more effective chemotherapy regimens (Folfirinox and Gem-Cap) and the implementation of radiotheraphy associated to chemotherapy showed greater tumour response whilst improved acute perioperative care has reduced the postoperative mortality after complex pancreatic surgery. The association of these advances to arterial resection could potentially have an impact on the overall survival and perioperative outcome for patients with locally advanced pancreatic cancer requiring concomitant arterial resection. The intention of this study is therefore to design an algorithm and strict inclusion criteria to identify those patients who might benefit from an aggressive surgical approach and to prospectively collect standardised data to assess the safety and possibly efficacy of AR in surgery for locally advanced pancreatic cancer.

• REC name

  London - Brent Research Ethics Committee

• REC reference

  14/LO/0504

• Date of REC Opinion

  15 Apr 2014

• REC opinion

  Further Information Favourable Opinion