Arterial haemodynamics in patients with aortic dissections
Research type
Research Study
Full title
Perfusion optimisation for the design of vascular grafts used in the treatment of aortic disease
IRAS ID
287048
Contact name
Asimina Kazakidi
Contact email
Sponsor organisation
University of Strathclyde
Clinicaltrials.gov Identifier
130285, RKES
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Cardiovascular diseases such as aortic dissections affect portions of the large artery known as the aorta, resulting in a tear in the vessel wall and creation of a false lumen. In advanced cases, there is a tendency for the vessel to expand and rupture in the absence of surgical intervention, leading to significant internal bleeding. Consequently, stent grafts are implemented to replace the diseased section of the aorta. However, it is important to optimise perfusion through the branch vessel in patient-specific cases to improve surgical outcome.
This project aims to investigate computationally the pre-surgical blood perfusion in diseased vessels and arterial haemodynamics. For this reason, we wish to study a group of patients with known aortic dissections.
We aim to perform secondary analysis of existing computed tomography (CT) images. These images are part of existing regular clinical screening and no new CT scans will be conducted to any patient for the purpose of this research. The images will be processed only after they are encrypted and fully anonymised (all metadata and patient information will be completely removed) by the clinicians at the hospital.
The CT images will be used to reconstruct the geometry of these blood vessels to generate patient-specific computational models, permitting visualisation of blood flow and computation of haemodynamic parameters. Further, the CT images will serve as a gold standard to allow validation of the same vessel reconstruction through previously reconstructed through different methods.REC name
South East Scotland REC 01
REC reference
20/SS/0118
Date of REC Opinion
11 Nov 2020
REC opinion
Favourable Opinion