Arterial haemodynamics in children and adolescents
Research type
Research Study
Full title
Arterial haemodynamics in children and adolescents (contributing to the European project CALLIRHEO)
IRAS ID
252866
Contact name
Asimina Kazakidi
Contact email
Sponsor organisation
University of Strathclyde
Clinicaltrials.gov Identifier
NHS R&D Reference Number, GN18CA492P
Duration of Study in the UK
1 years, 3 months, 17 days
Research summary
Cardiovascular diseases affect the cardiovascular system, i.e. the heart, the arteries, and the veins. The causes of cardiovascular disease may vary but the most common reason is atherosclerosis, a disease on the walls of the arteries that results in the narrowing of the blood vessels and obstruction of blood flow. It is believed that blood flow itself affects the location of atherosclerosis. This project aims to investigate computationally the arterial heamodynamics in children and adolescents, in relation to obesity and cardiovascular risk. For that reason, we wish to study a group of young patients (girls aged 12-18 years old) who, due to a genetic disorder (Turner syndrome), may or may not be obese and present increased cardiovascular risk. The reason we choose this age group is because age is found to be important in cardiovascular diseases and atherosclerosis. For this research, we aim to seek patient consent and perform secondary analysis of existing MRI images, from the Royal Hospital for Children (RHC), Queen Elizabeth University Hospital (QEUH) in Glasgow. The images are part of existing regular clinical screening and no new MRI scans will be conducted to any patient for the purpose of this research. The images are sited as existing datasets in the NHS Royal Hospital for Children, QEUH and will be processed only after they are encrypted and fully anonymised (all metadata and patient information will be completely removed) by the clinicians at the hospital. Patient-specific 3-D computational models will be constructed and will be used to visualise the blood flow in the aortic arch of this group of patients. The study will last for 1.5 years and it is funded by the European Commission Research Executive Agency (REA) via a Marie Skłodowska-Curie Fellowship.
REC name
London - Westminster Research Ethics Committee
REC reference
18/LO/2052
Date of REC Opinion
10 Dec 2018
REC opinion
Further Information Favourable Opinion