Arsenic exposure, pilot study, version 1
Research type
Research Study
Full title
Pilot study to measure arsenic exposure in ALSPAC participants
IRAS ID
194212
Contact name
Alix Groom
Contact email
Sponsor organisation
University of Bristol
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
The proposed research is for using biological material and data obtained for the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Initially recruited into the study were pregnant women between 1991 and 1992. The children arising from the pregnancies and their family members have been followed up since that time and an extensive amount of biological material and data is available for the study.
Arsenic exposure is a public health problem in adults and children because it is associated with increased risk of a variety of cancers and growth/developmental problems, respectively. Arsenic exposure has not been measured in the ALSPAC participants but preliminary analyses with genotypes associated with arsenic metabolism has shown differences in children's IQ. Determining the extent to which ALSPAC mothers and children have been exposed to arsenic is therefore an important research question to address.
A pilot study will be initially carried out to analyse arsenic metabolites in urine from the ALSPAC children when they were 10 years old. These samples were collected between 2001-2003.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
16/EM/0072
Date of REC Opinion
17 Feb 2016
REC opinion
Further Information Favourable Opinion