Arrhythmia risk in conduction system pacing [RIPCORD-CRT V8]
Research type
Research Study
Full title
RIPCORD-CRT: Randomised Investigation of Physiological, Conventional and Optimised Resynchronisation Therapy in Heart Failure with Prolonged QRS Duration.
IRAS ID
342311
Contact name
Jack W Samways
Contact email
Sponsor organisation
Research Governance and Integrity Team (RGIT) and Imperial College Healthcare NHS Trust
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Heart failure describes when the heart cannot pump enough blood for the body. Some patients with heart failure have small scars which cause the right and left sides of the heart to beat at different times. To fix this, doctors put in a special pacemaker device with wires in both sides of the heart making them beat at the same time. This is called biventricular pacing (BVP). BVP improves the heart’s pumping function, but can increase the risk of dangerous heart-rhythms. There is a new type of pacemaker that improves the heart’s pumping ability more naturally, called conduction system pacing (CSP). We are unsure how CSP affects the risk of the dangerous heart-rhythms in the long-term.
We will compare the newer CSP to the older BVP to see which is better at improving the pumping function and lowering the risk of dangerous heart-rhythms. To measure this risk, patients will wear jackets containing hundreds of heart-rhythm sensors to assess the heart’s electrical system from every angle. If CSP doesn’t improve the timing of the heartbeat completely, we will use a combination of CSP and BVP and measure that.
This research will help us understand which type of pacemaker improves the heart's pumping function best and has the lowest risk of abnormal heart-rhythms.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
25/NW/0269
Date of REC Opinion
2 Oct 2025
REC opinion
Further Information Favourable Opinion