ARISE - Vitamin D
Research type
Research Study
Full title
Anti-inflammatories to Reverse Immune Senescence in the Elderly (ARISE) – Vitamin D
IRAS ID
214761
Contact name
Arne Akbar
Contact email
Clinicaltrials.gov Identifier
Z6364106/2017/01/23 , UCL data protection number
Duration of Study in the UK
1 years, 7 months, 31 days
Research summary
As people get older, changes in the immune system lead to more frequent infectious diseases and less benefit from vaccination. Injection of extracts of bacteria and viruses into the skin provides a strategy to test human immune responses. These techniques have previously been used to show that immune responses are diminished and inflammation levels are increased in older adults. One possible reason for this is that older adults often have low levels of vitamin D - the sunshine vitamin - which is known to be important for the immune system. The aim of this study is to increase our understanding of how vitamin D affects immune responses to bacteria and viruses in older adults who have low vitamin D levels. The information we generate will be used to develop new approaches to counter adverse effects of ageing on immune responses.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
17/SC/0196
Date of REC Opinion
20 Jul 2017
REC opinion
Further Information Favourable Opinion