ARCADIA. Association of ncRNAs with CAD and type 2 diabetes
Research type
Research Study
Full title
Identification and characterisation of non-coding RNAs associated with coronary artery disease and diabetes in patients undergoing cardiac surgery.
IRAS ID
134721
Contact name
Gianni Angelini
Contact email
Duration of Study in the UK
2 years, 6 months, 2 days
Research summary
Genes hold the information to build and maintain human characteristics. They contain the code to produce proteins which perform many functions within our body. Genes (consisting of deoxyribonucleic acid -DNA expressed) do not produce proteins directly, but with the help of specialised molecules consisting of ribonucleic acid (RNA) called messenger RNA molecules (mRNAs). Recently, scientists have discovered the existence of a different type of RNA molecules: “non-coding” RNAs (ncRNA). The ncRNAs control the amounts of mRNA and/or their ability to produce proteins. Some ncRNAs can aggravate heart conditions while others can have positive effects. Several ncRNAs are present in the blood and urine and we think they may be possible indicators of disease or of the effects of cardiac surgery. The full range of ncRNAs is not yet known. In this study, we propose to use state-of-the-art research methods to identify and measure all the ncRNAs present in the human heart and investigate if their levels are affected by the extent to which the arteries supplying the heart are diseased and whether participants have type 2 diabetes or not. We also want to investigate whether we can measure ncRNAs in blood, urine and other tissue leftover from cardiac surgery (fluid from around the heart and pieces of vein left over after making grafts) and use them to predict whether patients will develop complications after their operations. This research study is important because it could help identify therapies to improve the recovery of the patient after cardiac surgery.
REC name
London - Fulham Research Ethics Committee
REC reference
13/LO/1687
Date of REC Opinion
20 Dec 2013
REC opinion
Further Information Favourable Opinion