Aqueous Dynamics and MicroPulse Laser
Research type
Research Study
Full title
The Effect of Transscleral MicroPulse® Laser Cyclophotocoagulation on Aqueous Dynamics in Patients with Glaucoma or Ocular Hypertension: An Observational Study
IRAS ID
232676
Contact name
K Sheng Lim
Contact email
Sponsor organisation
Guy's & St Thomas' Foundation NHS Trust
Duration of Study in the UK
2 years, months, days
Research summary
There are currently many surgical options for patients with glaucoma and/or ocular hypertension (OHT) that is not adequately controlled by eye drops, however, little is known about how the different surgical techniques used to treat glaucoma affect the flow of fluid through and out of the eye (aqueous dynamics). In this study we will investigate the effect of the MicroPulse Laser procedure used to treat glaucoma or OHT on aqueous dynamics. 35 patients with glaucoma or ocular hypertension listed to undergo the MicroPulse Laser procedure will be included in a prospective observational study using their contralateral non-operated eye as control to study the effect of the MicroPulse Laser on aqueous dynamics and also the influence of baseline aqueous dynamics on the outcome of the surgery. Patients with glaucoma or ocular hypertension who have been listed for MicroPulse Laser surgery will be invited to participate in this study.
Participants will undergo some pre-operative baseline measurements that are additional to routine care, including measures of aqueous dynamics parameters (intraocular pressure, tonographic outflow facility and morning aqueous humour production) four weeks after stopping to use their eye drops for glaucoma. Follow-up data will be collected at routine follow up appointments 1 day, 1 week, 1 month, 3 months, and 6 months after surgery, but the aqueous dynamics parameters measurements and all other tests additional to routine care will only be repeated at the follow up visit 6 months after surgery. Before the 6 month follow-up visit when aqueous dynamics parameters will be measured participants will be asked to stop using any eye drops that they may still be using to treat their glaucoma or OHT after the surgery. Paired Student t-tests will be used to compare aqueous dynamics parameters before and after surgery.
REC name
London - Queen Square Research Ethics Committee
REC reference
18/LO/0440
Date of REC Opinion
23 Mar 2018
REC opinion
Favourable Opinion