Aqueous Dynamics and Glaucoma Surgery
Research type
Research Study
Full title
The Effect of Glaucoma Surgery on Aqueous Dynamics in Patients with Glaucoma or Ocular Hypertension: An Observational Study
IRAS ID
163050
Contact name
K Sheng Lim
Contact email
Sponsor organisation
Guy's & St Thomas' Foundation NHS Trust
Duration of Study in the UK
2 years, months, days
Research summary
There are currently many surgical options for patients with glaucoma and ocular hypertension, including Hydrus, HIFU, Diode laser, trabeculectomy and Baerveldt implants, but little is known about how the different surgical techniques used to treat glaucoma affect the flow of fluid through and out of the eye (aqueous dynamics).
One hundred eyes of 100 patients with glaucoma or ocular hypertension will be included in a prospective observational study using their contralateral non-operated eye as control to study the effect of glaucoma surgery on aqueous dynamics and also the influence of baseline aqueous dynamics on the eventual outcome of the different surgical techniques. All patients with glaucoma or ocular hypertension who have been listed for glaucoma surgery will be invited to participate in this study.
Patients will undergo some pre-operative baseline measurements that are additional to routine care, including aqueous dynamics parameters (intraocular pressure, tonographic outflow facility and morning aqueous humour production), four weeks after stopping to use their eye drops for glaucoma. Intraocular pressure will be measured by a pneumatonometer, the outflow facility will be measured by electronic Schiøtz tonography, and the aqueous flow rate will be measured by fluorophotometry. The uveoscleral outflow will be calculated using the Goldmann equation. Follow-up data will be collected 1 day, 1 week, 1 month, 3 months, 6 months and 12 months after surgery. Measurement of aqueous dynamics parameters and other tests additional to routine care will be repeated 3 months and 12 months after surgery. Before the 3 and 12 month follow-up visits when of aqueous dynamics parameters will be measured, participants will be asked to stop using any eye drops that they may still be using to treat their glaucoma after the surgery. Paired Student t-tests will be used to compare aqueous dynamics parameters before and after surgery.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
15/LO/1809
Date of REC Opinion
29 Feb 2016
REC opinion
Further Information Favourable Opinion