APAChe
Research type
Research Study
Full title
Adaptive Radiotherapy Planning for Upper Abdominal Tumours in Children and Teenagers
IRAS ID
195329
Contact name
Henry Mandeville
Contact email
Sponsor organisation
Royal Marsden NHS Foundation Trust
Duration of Study in the UK
1 years, 1 months, 1 days
Research summary
Radiotherapy treatment and planning has become increasingly sophisticated. Advanced techniques can reduce the amount of normal tissue exposed to high doses of radiation. When these methods are used in areas of the body affected by breathing-related motion visualising the motion is potentially important for maintaining accurate treatment delivery. Studies are needed to see if young patients can potentially benefit from individual measurement of motion as part of the radiotherapy planning process. Ways to measure motion without exposing patients to extra radiation need to be developed as do ways to reduce motion if the motion seen is significant. This study will focus on the upper abdomen in young patients and will use three types of four-dimensional (4D) imaging techniques to measure motion. 4D-imaging looks at anatomy over the course of a number of minutes. This then allows the range of movement for targets and important nearby organs to be assessed. The aim of this study is to measure this motion for kidney(s), liver and tumour/ tumour bed (some patients will have had their tumours removed by surgery). The results of this study will give a measure of motion in the patients recruited. If the motion measured for a range of ages in childhood and young adulthood is significant then we can identify whether methods to reduce this movement are necessary to use in the radiotherapy planning and treatment process (breath hold). This study explores how breathing effects the way planned dose is delivered in reality and how knowledge of the degree of motion for an individual patient might impact on the treatment volume compared to planning with a generic ‘catch all’ volume.
REC name
London - Riverside Research Ethics Committee
REC reference
16/LO/1390
Date of REC Opinion
13 Oct 2016
REC opinion
Favourable Opinion