AO in PVR Study

• Research type

  Research Study

• Full title

  An observational study of retinal function and structure after repair of macula-involving retinal detachment complicated by proliferative vitreoretinopathy (RD-PVR) using adaptive optics.

• IRAS ID

  221084

• Contact name

  David Charteris

• Contact email

  david.charteris@moorfields.nhs.uk

• Sponsor organisation

  Moorfields Eye Hospital

• Duration of Study in the UK

  0 years, 11 months, 27 days

• Research summary

  The purpose of this study is to investigate the loss of retinal cells following retinal detachment surgery using an imaging device called an adaptive optics camera.

  The retina is a thin layer which lines the back of the eye. It is sensitive to light (like the film in a camera) and is necessary for vision. If a hole or rip develops in a retina it can become detached. The macula is the central portion of the retina which we use for fine vision. This area can also become detached as part of a retinal detachment. Proliferative vitreoretinopathy (PVR) is an abnormal scarring response inside the eye which can occur when the retina detaches. It can adversely affect the outcome of the retinal detachment repair and is associated with a worse visual prognosis.

  We want to investigate retinal cell loss in patients with retinal detachments that have developed PVR when the macula has been involved. We plan to compare them to two other groups of patients, who have not developed PVR:
  1) Patients with macula-involving retinal detachments without PVR
  2) Patients with macula-sparing detachments without PVR

  We will investigate retinal cell loss in these types of retinal detachments using adaptive optics imaging. This is a non-invasive imaging technique which allows us to view the retina at very high magnification. Investigating photoreceptor loss and its association with visual outcome in this way should help to guide future interventions in promoting retinal regeneration.

  We plan to recruit 25 patients at one UK hospital. The project is funded by the charity Fight for Sight.

• REC name

  London - Fulham Research Ethics Committee

• REC reference

  17/LO/0132

• Date of REC Opinion

  30 Jan 2017

• REC opinion

  Further Information Favourable Opinion