Antipsychotic minimsation recruitment study
Research type
Research Study
Full title
Research into Antipsychotic Discontinuation and Reduction (RADAR) Recruitment Study
IRAS ID
188655
Contact name
Joanna Moncrieff
Contact email
Sponsor organisation
North East London NHS Foundation Trust
Duration of Study in the UK
0 years, 8 months, 30 days
Research summary
The current study is a preparatory study for a randomised controlled trial that will be designed to compare a gradual strategy of antipsychotic reduction (antipsychotic minimisation) with maintenance (continuous) treatment in people with schizophrenia or recurrent psychotic episodes. The current study aims to assess the proportion of people with recurrent psychosis or schizophrenia who would be eligible and willing to enter a controlled trial such as the one proposed.
We will identify potential participants through Community Mental Health services. Potential participants will initially be contacted by a member of the clinical team. If they consent, they will be contacted by the research team, and a research assessment will be set up. During the assessment the researcher will ask questions about the participant's experience with antipsychotic medication, and participants will be asked to fill in a short validated questionnaire about their attitudes to this medication. Information about the proposed trial will be given, and participants will be asked whether they would agree to enter such a trial. Reasons for agreeing or not agreeing will be explored.
Patients from some General Practices will also be approached to see if they would enter the Recruitment Study, and they will receive the same research interview if they consent to it.
The data will be used to assess the proportion of people in services who would be eligible and willing to enter a randomised controlled trial of an antipsychotic minimsation strategy. The characteristics of interview participants who say they would take part, and those who would not will be compared. The data will facilitate an effective recruitment strategy for the proposed trial, and will provide information about the generalisiability of long-term antipsychotic trials.
REC name
East of Scotland Research Ethics Service REC 2
REC reference
15/ES/0163
Date of REC Opinion
20 Oct 2015
REC opinion
Further Information Favourable Opinion