Antimicrobial Susceptibility in ESBL-producing Enterobacteriaceae
Research type
Research Study
Full title
Surveillance of the antimicrobial susceptibility patterns of extended-spectrum beta-lactamase-producing Enterobacteriaceae in an acute NHS Trust
IRAS ID
152972
Contact name
Christopher Dyson
Contact email
Sponsor organisation
North Tees and Hartlepool NHS Foundation Trust
Research summary
Bacterial resistance to every antimicrobial in use has been reported, albeit to varying extents. Increasing resistance levels is a global problem; clinicians everywhere have encountered problems with resistant organisms causing serious infections. There are a very large number of mechanisms of resistance to the different classes of antibiotics. This study focuses on extended-spectrum beta-lactamase (ESBL) -producers belonging to the bacterial family Enterobacteriaceae. ESBL confers resistance to many agents in the beta-lactam group including the penicillins, cephalosporins and the oxyimino-monobactam aztreonam. The study centres upon ascertaining the antimicrobial resistance patterns of ESBL-producing isolates from patients in the Stockton-On-Tees and Hartlepool areas. The data will be represented as percentage resistance rates and the influence of these on antibiotic prescribing will be considered. There may be an opportunity that local clinicians will have accurate rates of resistance upon which to base empirical antibiotic prescribing. It is also possible that the data will assist in the review of future antibiotic stewardship policies.
REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
14/LO/1422
Date of REC Opinion
4 Sep 2014
REC opinion
Further Information Favourable Opinion