Antimicrobial resistance for Neisseria gonorrhoeae version 9 18/02/16
Research type
Research Study
Full title
A pilot study to determine the risk factors associated with antimicrobial resistance for Neisseria gonorrhoeae
IRAS ID
189035
Contact name
Jayshree Dave
Contact email
Sponsor organisation
Barts Health NHS Trust
Duration of Study in the UK
0 years, 5 months, 30 days
Research summary
Antibiotic resistance for Neisseria gonorrhoeae is detected nationally by the gonococcal resistance antimicrobial surveillance programme (GRASP). Organisms (isolates) are collected from 24 laboratories across England and Wales and epidemiological data is collected from 26 genito-urinary medicine (GUM) clinics from July to September for the sentinel surveillance programme. Gonorrhoea is the second most common bacterial sexually transmitted infection in England and in 2013 diagnoses increased by a notable 15% (25,577 to 29,291). The highest rates of gonorrhoea diagnoses occur in London. Barts Health microbiology laboratory does not participate in GRASP. We want to determine the risk factors associated with antimicrobial resistance in Neisseria gonorrhoeae by using existing laboratory data (minimum inhibitory concentrations and whole genome sequencing) on anonymised gonococcal isolates. This project will help us to understand the local epidemiology within our population by examining the relationship between antibiotic susceptibility testing, epidemiology and outcome for gonococcus in our population. High-throughput sequencing technologies are accelerating our understanding of bacterial diversity and the generation and transmission of antimicrobial resistance.
In this study we aim to undertake a retrospective case review of patient notes to obtain anonymised data to link risk factors for antimicrobial resistance and understand the molecular epidemiology and diversity of circulating gonococcal strains and put these into a global context. Additionally we aim to look at the relationship between the genotype and reduced antibiotic susceptibilities and investigate the intraspecies transmission of antimicrobial resistance genes.Our objective is to determine the risk factors for antimicrobial resistance in Neisseria gonorrhoeae in East London. This will involve a) linking risk factor data with accurate antimicrobial resistance data obtained by measuring the minimum inhibitory concentration (MICs) of the antibiotics used for treatment for each strain.
b) investigate the value of whole genome sequencing to predict resistance based on the presence of known resistance genes.REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
16/WM/0238
Date of REC Opinion
12 May 2016
REC opinion
Favourable Opinion