Antibody incompatible transplantation- a prospective study
Research type
Research Study
Full title
Antibody incompatible transplantation- a prospective study
IRAS ID
204733
Contact name
Caroline Dudreuilh
Contact email
Sponsor organisation
Guy’s and St Thomas’ NHS Foundation Trust
Duration of Study in the UK
9 years, 8 months, 30 days
Research summary
Some patients who need a kidney transplant have antibodies against their donor, and for the transplant to go ahead these antibodies need to be removed; this is termed antibody incompatible transplantation. This is being performed in only a few centres in the UK, but is increasingly common, as more and more patients on the waiting list have antibodies. Guys Hospital has the largest antibody incompatible transplant programme in the UK. However, this form of transplantation carries more risks than conventional transplantation, with a higher mortality rate, an increased chance of rejection and more infections. There is little data available on the detailed outcomes of such transplants, and predicting which patients will have a poor outcome is difficult. This project aims to prospectively study all patients undergoing (or who have already undergone) antibody incompatible transplantation at Guys, Evelina and Great Ormond Street Hospitals, and to collect demographic and outcome data. Samples of blood will be taken at the same time as blood is taken for clinical purposes at clinic follow-up visits, and urine samples will also be collected; these samples will be analysed using cellular, biochemical and genetic techniques in order to better understand the mechanisms of both acute and chronic rejection. Surplus samples of any biopsies taken of the kidney transplant may be used to determine mechanisms of rejection or protection from the effects of antibodies.
REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
16/WM/0370
Date of REC Opinion
7 Oct 2016
REC opinion
Further Information Favourable Opinion