Anthem 1
Research type
Research Study
Full title
Nurse Facilitated Adherence Therapy for Haemophilia (AnTHem Trial) –A Cluster Randomised Controlled Trial
IRAS ID
139940
Contact name
Martin Bedford
Contact email
Research summary
The purpose of this study is to determine if nurse facilitated adherence therapy for haemophilia(AnTHem) improves patient adherence to clotting factor replacement therapy, clinical appointments and health advice; and, affects the level of patient engagement and ownership of treatment.
Clotting factor prophylaxis is the most effective method for preventing both life threatening bleeds and the long term muscular and skeletal consequences of bleeding. The literature indicates that up to 20% of people living with haemophilia are not fully adherent with their prescribed therapy. This may have considerable impact on treatment efficacy and expose individuals to the significant impact of their disorder.
Adherence therapy is a brief individual approach aimed at facilitating a process of shared decision making where service users and clinicians work toward agreed goals. The intervention consists of six phases which form the core of the therapy. Assessment; treatment problem solving; treatment timeline; exploring ambivalence; discussing beliefs and concerns about treatment; and, treatment in the future. The aim is to achieve a mutual decision about medication between the individual and the clinician.
The trial aims to compare AnTHem to treatment as usual (TAU) for people with haemophilia treated at 10 haemophilia comprehensive care centres across the UK . Centres will be randomised into AnTHem and TAU and TAU.REC name
South Central - Oxford A Research Ethics Committee
REC reference
13/SC/0549
Date of REC Opinion
25 Nov 2013
REC opinion
Further Information Favourable Opinion