Anorectal function in perianal Crohn's disease.
Research type
Research Study
Full title
EVALUATION OF ANORECTAL FUNCTION IN PERIANAL CROHN’S DISEASE: A PILOT STUDY.
IRAS ID
255531
Contact name
Christian Selinger
Contact email
Sponsor organisation
Leeds Teaching Hospitals NHS Trust
Duration of Study in the UK
0 years, 7 months, 30 days
Research summary
Perianal Crohn’s disease is a disabling disease associated with increased morbidity and impaired quality of life. It is associated with pain, discharge, fecal incontinence and sexual and psychological impairment. In refractory cases, a stoma may be necessary. A higher prevalence is seen with increasing Crohn’s disease duration and appears to vary according to the disease location. The presence of symptoms associated with anorectal dysfunction, such as fecal incontinence, can sometimes poorly correlate with the presence of anal sphincter abnormalities. Moreover, even in patients without symptoms, the presence of anal sphincter abnormalities may have important implications for the future selection of type of delivery, and might even pose a contra-indication for certain types of anorectal surgeries.
Studies evaluating possible chronic complications of perianal Crohn's disease on anorectal function are lacking. There is a need for a better understanding of the chronic complications of this disease, and the role of high-resolution anorectal manometry in diagnosing these abnormalities during follow-up of these patients. This study will evaluate the chronic repercussions of perianal Crohn’s disease in patients with a previous anal fistula and/or abscess that has healed and/or is inactive.REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
18/NW/0850
Date of REC Opinion
10 Jan 2019
REC opinion
Favourable Opinion