Analysis of urine from the ALSPAC study v1.0
Research type
Research Study
Full title
Microalbuminuria: causes and long-term consequences in the general population.
IRAS ID
259947
Contact name
Alix Groom
Contact email
Sponsor organisation
University of Bristol
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
The proposed research is for using biological material and data obtained for the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Initially recruited into the study were pregnant women between 1991 and 1992. The children arising from the pregnancies and their family members have been followed up since that time and an extensive amount of biological material and data is available for the study.
This proposal is for the analysis of urine that has been collected from the offspring at a number of time points, as well as from the mother during pregnancy. As extensive data is available on the participants, exposures and/or biomarkers can be analysed against specific outcomes.
Albumin is a protein present in blood and excreted in urine. Slight increases of levels of albumin excretion in urine (microalbuminuria) are related to an increased risk for renal and cardiovascular disease. The exact cause and the underlying mechanism of microalbuminuria are still unknown and there is limited data on microalbuminuria in young individuals.
To investigate the causes and outcomes of microalbuminuria urine will be analysed for levels of albumin, creatinine, urea, sodium and potassium. These will then be analysed against genetic background, renal, cardiovascular and metabolic outcomes and, for the offspring, antenatal and perinatal factors.
REC name
London - Central Research Ethics Committee
REC reference
19/LO/1485
Date of REC Opinion
4 Nov 2019
REC opinion
Favourable Opinion